Protocols

Extraction of Aβ From Brain for Application to Aβ ELISA

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PI: Takaomi Saido
Affiliation: RIKEN Brain Science Institute
Submitted by: Nobuhisa Iwata
Posted Date: 24 Feb 2009

Brief Description

This protocol is a method to extract Aβ from brain tissues for application to Aβ ELISA.

References

  1. . Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy. Neurosci Res. 2006 Apr;54(4):235-53. PubMed.
  2. . Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. J Biol Chem. 2006 Jun 30;281(26):17941-51. PubMed.
  3. . Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation. Nat Med. 2005 Apr;11(4):434-9. PubMed.
  4. . Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. J Neurosci. 2004 Jan 28;24(4):991-8. PubMed.
  5. . Metabolic regulation of brain Abeta by neprilysin. Science. 2001 May 25;292(5521):1550-2. PubMed.

Keywords

Aβ, ELISA, brain

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