. YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease. Biol Psychiatry. 2010 Nov 15;68(10):903-12. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)
Cohort
(N)
Measurement
Mean ± SD
Method;
Assay Name;
Manufacturer
Diagnostic
Criteria
Aβ1-42
(CSF)
AD-
Mild AD
(29)
351 ± 118
pg/mL
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
Aβ1-42
(CSF)
AD-
Very Mild AD
(65)
446 ± 230
pg/mL
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
Aβ1-42
(CSF)
CTRL-
CNC
(198)
605 ± 240
pg/mL
ELISA;
Innotest;
Innogenetics
YKL-40
(CSF)
AD-
Mild AD
(24)
422.2 ± 30†
ng/mL
ELISA;
Other/Not Specified;
Quidel Corp.
McKhann et al., 1984
YKL-40
(CSF)
AD-
Mild AD
(29)
351.7 ± 22.6†
pg/mL
ELISA;
Other/Not Specified;
Quidel Corp.
McKhann et al., 1984
YKL-40
(CSF)
AD-
Very Mild AD
(65)
358.9 ± 16.9†
pg/mL
ELISA;
Other/Not Specified;
Quidel Corp.
McKhann et al., 1984
YKL-40
(CSF)
CTRL-
CNC
(198)
282.1 ± 6.7†
pg/mL
ELISA;
Other/Not Specified;
Quidel Corp.
YKL-40
(CSF)
CTRL-
CNC
(24)
293.6 ± 23.9†
ng/mL
ELISA;
Other/Not Specified;
Quidel Corp.
YKL-40
(Plasma)
AD-
Mild AD
(29)
91.9 ± 15†
pg/mL
ELISA;
Other/Not Specified;
Quidel Corp.
McKhann et al., 1984
YKL-40
(Plasma)
AD-
Very Mild AD
(65)
81.1 ± 8†
pg/mL
ELISA;
Other/Not Specified;
Quidel Corp.
McKhann et al., 1984
YKL-40
(Plasma)
CTRL-
CNC
(198)
62.5 ± 3.4†
pg/mL
ELISA;
Other/Not Specified;
Quidel Corp.
tau-p181
(CSF)
AD-
Mild AD
(29)
77 ± 38
pg/mL
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-p181
(CSF)
AD-
Very Mild AD
(65)
85 ± 44
pg/mL
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-p181
(CSF)
CTRL-
CNC
(198)
55 ± 25
pg/mL
ELISA;
Innotest;
Innogenetics
tau-total
(CSF)
AD-
Mild AD
(29)
552 ± 263
pg/mL
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-total
(CSF)
AD-
Very Mild AD
(65)
539 ± 276
pg/mL
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-total
(CSF)
CTRL-
CNC
(198)
304 ± 161
pg/mL
ELISA;
Innotest;
Innogenetics

† Mean ± SEM

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