Hampel H, Teipel SJ, Fuchsberger T, Andreasen N, Wiltfang J, Otto M, Shen Y, Dodel R, Du Y, Farlow M, Möller HJ, Blennow K, Buerger K. Value of CSF beta-amyloid1-42 and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment. Mol Psychiatry. 2004 Jul;9(7):705-10. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : Aβ42 (CSF)
- CTRL vs AD : Aβ42 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
AD (93) |
545 ± 230 ng/L |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| Aβ42 (CSF) |
CTRL- CNC (10) |
962 ± 182 ng/L |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
AD (93) |
725 ± 266 ng/L |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-total (CSF) |
CTRL- CNC (10) |
341 ± 118 ng/L |
ELISA; Innotest; Innogenetics |
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Comments
Inserm
A very useful biological confirmation that the drop of Abeta 1-42 in the CSF of MCI patients predicts the coming of Alzheimer's disease.
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