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  1. The analysis of the pleitropic effects of Valsartan is striking. The potential of a class effect amongst the sartan drug family should be investigated further. Several of the inactive compounds in the first assay round are not the real Valsartan competing agent: Losartan (a primary alcohol) is active as its acidic metabolite EXP3174; Candesartan Cilexitil is a prodrug, which requires metabolic activation.

    Tasosartan, Telmisartan and Irbesartan lack a crucial acid moiety common to the other three.


    . Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites. J Med Chem. 2003 Jun 5;46(12):2261-70. PubMed.