. Using intramolecular disulfide bonds in tau protein to deduce structural features of aggregation-resistant conformations. J Biol Chem. 2012 Mar 16;287(12):9591-600. PubMed.

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  1. This is an interesting paper. However, 3R-tau, which has only one cysteine, is not mentioned at all, and in AD, both 4R and 3R tau form aggregates. It might be interesting in subsequent studies to include a 3R truncated form similar to the K18 construct. I would also be interested to see whether full-length 4R tau behaves similarly to the K18 truncated form.