Alves-Rodrigues A, Gregori L, Figueiredo-Pereira ME.
Ubiquitin, cellular inclusions and their role in neurodegeneration.
Trends Neurosci. 1998 Dec;21(12):516-20.
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On the basis of the abstract of this article it appears the authors assume that inclusions of ubiquitinated proteins is harmful rather than innocent by-products or attempts of the cell to deal with pathological processes. The assumption that seem to be made by the authors may or may not be correct.