Cao X, Südhof TC.
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.
Science. 2001 Jul 6;293(5527):115-20.
PubMed.
AICD is produced after the γ-secretase proteolysis process. It is similar to NICD as a transcript factor. This paper provides us with the information that APP may function by releasing AICD. Although the target gene of AICD is still unclear, it has been attracting much attention.
Comments
Brigham & Women's Hospital
A landmark paper demonstrating that APP intracellular domain is involved in transcriptional regulation.
AICD is produced after the γ-secretase proteolysis process. It is similar to NICD as a transcript factor. This paper provides us with the information that APP may function by releasing AICD. Although the target gene of AICD is still unclear, it has been attracting much attention.
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