Medina MG, Ledesma MD, Domínguez JE, Medina M, Zafra D, Alameda F, Dotti CG, Navarro P.
Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation.
EMBO J. 2005 May 4;24(9):1706-16.
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This paper describes a detailed (and convincing) signal transduction pathway by which amyloid kills neurons. It's a real breakthrough.