. Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron. 2010 Dec 22;68(6):1067-81. PubMed.

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  1. This is nice work by Hoover and colleagues providing yet another piece of important evidence for the role(s) of tau in the post-synapse. While we showed before that endogenous mouse tau is associated with the post-synaptic density (PSD) (Ittner et al., 2010), this study now reveals that upon overexpression of human tau, even more tau is associated with the PSD (in particular, when the P301L mutations is present), which then impairs the normal function of synapses. I am particularly intrigued by the fact that (hyper)phosphorylation of tau specifically promotes its localization to dendritic spines.

    References:

    . Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. 2010 Aug 6;142(3):387-97. PubMed.