Lapointe NE, Horowitz PM, Guillozet-Bongaarts AL, Silva A, Andreadis A, Binder LI.
Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro.
Biochemistry. 2009 Dec 29;48(51):12290-7.
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This is a very interesting paper. It indicates that a new tau isoform, other than the conventional 6 isoform, plays an inhibitory role in tau aggregation. If we could regulate the expression of this alternative splicing by a chemical compound, and increase the expression of the tau 6D/6P isoform, then NFT formation would supposedly be blocked in AD patients. We need to know if the 6D/6P isoform also inhibits tau oligomer formation after tau hyperphosphorylation. I would like to know what happens on behavior and pathology, when the 6D/6P isoform is overexpressed in tau transgenic mice.