Yan Y, Liu Y, Sorci M, Belfort G, Lustbader JW, Yan SS, Wang C.
Surface plasmon resonance and nuclear magnetic resonance studies of ABAD-Abeta interaction.
Biochemistry. 2007 Feb 20;46(7):1724-31.
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My collaborators, Dr. Wang's group, extended our initial studies and
just published NMR results on Aβ-ABAD binding, which forms a direct
link between Aβ and mitochondrial toxicity. This paper examined the
thermodynamics as well as conformational and functional consequences
of the Aβ-ABAD interaction. Surface plasma resonance showed that
the binding between Aβ and ABAD is mainly driven by hydrophobic
interactions. NMR clearly demonstrated that Aβ binding results in
the loss of the essential cofactor NAD from the ABAD enzyme. These new
data are important for understanding the mechanism of Aβ toxicity
and for the search for drugs that disrupt the Aβ-ABAD interaction
in Alzheimer disease.
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