. Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations. J Neurosci Res. 1999 Jun 1;56(5):457-70. PubMed.

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  1. This suggests superoxide production by PS-1 mutations. What remains to be seen is the relationship between radical species and amyloidgenesis, both of which were caused by PS-1.

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