Strange RW, Antonyuk S, Hough MA, Doucette PA, Rodriguez JA, Hart PJ, Hayward LJ, Valentine JS, Hasnain SS.
The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis.
J Mol Biol. 2003 May 9;328(4):877-91.
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Study of the 3D structure of Cu/Zn SOD1 wild type and its comparison with mutated forms is certainly a strong approach to decipher the causes of motoneuron death.