. Sporadic cerebral amyloid angiopathy is not a frequent cause of spontaneous brain hemorrhage. Eur J Neurol. 2007 Aug;14(8):923-8. PubMed.

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  1. I proposed (ICAD-2006, Madrid) that intracerebral bleedings observed in some amyloid mouse models have more to do with their genetic background than with CAA—based on our observations of only very rare bleedings, if any, in our APP-V717I mice (in FVB/N, or C57Bl or F1 background). That led me to suggest that also in patients, the genetic makeup would be most determining—rather than CAA, per se. The data presented by Dr. Jellinger and his coworkers corroborate the hypothesis. I wonder whether the same holds for micro-bleedings in humans, which we also observe rarely in our amyloid mouse model.

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