McLean CA, Cherny RA, Fraser FW, Fuller SJ, Smith MJ, Beyreuther K, Bush AI, Masters CL.
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease.
Ann Neurol. 1999 Dec;46(6):860-6.
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This report shifts the importance of Abeta in AD from the amyloid depositions to a soluble Abeta peptide. This shift is nessasary as there is good evidence that amyloid plaques may not be responsible for AD.