Satoh A, Brace CS, Rensing N, Cliften P, Wozniak DF, Herzog ED, Yamada KA, Imai S.
Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH.
Cell Metab. 2013 Sep 3;18(3):416-30.
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The role of SIR2 orthologs in modulating longevity is currently a subject of major debate. While overexpression ofSIR2 extends lifespan in yeast, studies in worms and flies remain inconsistent and whole body over expression of the mouse ortholog, SIRT1, failed to extend lifespan, although protection against some age-related diseases has been observed. This study from the Imai lab is important because it shows that overexpression of SIRT1 can extend mammalian lifespan. It is also interesting because increasing evidence implicates the role of the hypothalamus in regulating processes linked to aging. Imai’s work shows that the aging specific function of SIRT1 may relate to improved hypothalamic control of tissue communication and metabolism.