. Signal transduction through prion protein. Science. 2000 Sep 15;289(5486):1925-8. PubMed.


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  1. Coupling of cellular prion proteins to Fyn is a real surprise, but maybe it shouldn't be. Fyn keeps popping up. Shirazi and Wood showed that tangle-bearing neurons in AD have a hefty overload of Fyn. Gloria Lee showed Fyn and tau co-localize. Gail Johnson's group showed that Fyn stimulates AD-like tau phosphorylation via GSK 3β. Kandel and Grant tied Fyn to LTP, and we found that Fyn knockout stops ADDL from killing neurons. That two neurodegenerative diseases both are linked in some way to Fyn reminds me of Wilson's concept of " consilience," coming to the same truth from very different pathways. I can imagine the gods of science saying, "Well, here's another clue for you… Now can you figure it out?"

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  1. Normal Prion Protein Signals with Fyn