Capetillo-Zarate E, Staufenbiel M, Abramowski D, Haass C, Escher A, Stadelmann C, Yamaguchi H, Wiestler OD, Thal DR. Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology. Brain. 2006 Nov;129(Pt 11):2992-3005. PubMed.
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Banner Research Institute
A large body of work has shown regression/decreased plastic capacity in dendrites in AD (Flood and Coleman, 1990; Buell and Coleman, 1979; de Ruiter et al., 1987; Braak et al., 1994). It has often been assumed that these dendritic deficits related to cytoskeletal disruption consequent to tau phosphorylation. More recent evidence links functional deficits to Aβ oligomers (e.g., Lesne et al., 2006) as well as Aβ itself (Kelly et al., 2005). The present paper reintroduces fibrillar Aβ, now as a culprit in dendritic regression. Do the many flavors of Aβ have different consequences? Or are we faced with a need to more completely specify the forms of Aβ that are producing effects determined by optimally sensitive methods?
References:
Flood DG, Coleman PD. Hippocampal plasticity in normal aging and decreased plasticity in Alzheimer's disease. Prog Brain Res. 1990;83:435-43. PubMed.
Buell SJ, Coleman PD. Dendritic growth in the aged human brain and failure of growth in senile dementia. Science. 1979 Nov 16;206(4420):854-6. PubMed.
de Ruiter JP, Uylings HB. Morphometric and dendritic analysis of fascia dentata granule cells in human aging and senile dementia. Brain Res. 1987 Feb 3;402(2):217-29. PubMed.
Braak E, Braak H, Mandelkow EM. A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol. 1994;87(6):554-67. PubMed.
Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH. A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 2006 Mar 16;440(7082):352-7. PubMed.
Kelly BL, Vassar R, Ferreira A. Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease. J Biol Chem. 2005 Sep 9;280(36):31746-53. PubMed.
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