. S-2474, a novel nonsteroidal anti-inflammatory drug, rescues cortical neurons from human group IIA secretory phospholipase A(2)-induced apoptosis. Neuropharmacology. 2005 Aug;49(2):174-84. PubMed.


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  1. Given the termination of ADAPT, it may be many years before we know whether nonsteroidal drugs can truly inhibit or delay the onset of AD. Still, the strong observational evidence in favor of this idea warrants further investigation. Here is a paper showing a specific NSAID effect that suggests a postulated mechanism by which such drugs might retard the pathogenesis of AD. If this experimental drug is indeed a selective COX-2 inhibitor, that is important new information because, at present, there is little or no observational evidence base to address the potential protective effect of COX-2 selective NSAIDs on AD pathogenesis.

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