Catalano SM, Dodson EC, Henze DA, Joyce JG, Krafft GA, Kinney GG.
The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease.
Curr Top Med Chem. 2006;6(6):597-608.
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Catalano et al. hypothesize that disruption of fibrils could result in an increase of soluble Aβ oligomers. I want to test this hypothesis in vivo, specifically that disrupting fibrils leads to increases in ADDLs that correlates with cognitive deficits in non-transgenic Long-Evans rats.
My question is, What could I use that would disrupt and solubilize fibrils? I have heard of clioquinol, but I was wondering if there are other options that I am unaware of?