. Risk factors and preventive interventions for Alzheimer disease: state of the science. Arch Neurol. 2011 Sep;68(9):1185-90. PubMed.

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  1. Given the importance of magnesium (Mg) to brain function (Slutsky et al., 2010), it would seem to make sense to make sure older people are getting enough of this critical mineral. Mg plays an important role in protein kinases. Tyrosine-specific protein kinase and protein kinase M ζ are crucial to memory function. Protein kinase M ζ is also involved in insulin-stimulated glucose transport. Mg and insulin tightly regulate each other. (This is where Suzanne Craft's work on insulin and AD comes in.) Mildred Seelig found an interesting relationship among Mg, Ca, and estrogen (Seelig, 1990). It would be worth investigating if the current clinical recommendations for the treatment of osteoporosis are contributing to Mg deficiency and therefore aggravating the problem of dementia in the elderly. It would also be interesting to see if there is a correlation between AD and osteoporosis. Part of prevention should be making sure the elderly are getting enough Mg.

    References:

    . Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010 Jan 28;65(2):165-77. PubMed.

    . Increased need for magnesium with the use of combined oestrogen and calcium for osteoporosis treatment. Magnes Res. 1990 Sep;3(3):197-215. PubMed.

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