. Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice. J Neurosci. 2008 Aug 20;28(34):8624-34. PubMed.


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  1. It's interesting that TFAM can prevent age-dependent memory impairment and loss of neuronal function when overexpressed in transgenic mice. Telmisartan increases expression of TFAM and MTOC1 and has been found to prevent cognitive decline following intracerebroventricular injection of Aβ1-40 (1,2).

    Perhaps further reason to suspect benefit with Telmisartan therapy in AD and ALS is provided by Baden and colleagues who report that Telmisartan inhibits methylglyoxal induced caspase-3 activation. Methylglyoxal has been implicated in the formation of amyloid plaques and neurofibrillary tangles in AD. Rohn suggests that caspase-cleaved TDP-43 is a major pathological finding in AD (3,4,5).

    View all comments by Mary Reid

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  1. Aging and Aβ Hit Mitochondria Function