. Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model. J Neurosci. 2008 Nov 5;28(45):11622-34. PubMed.


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  1. To test if a retinoic acid can reduce amyloid deposition in vivo, the authors used the APPswe/PS mutant transgenic mouse model. It is unclear to me which mouse model was used in the current study. Although it was stated in the text that line85 APPswe/PS1delta9 mice were used, articles describing several other APP transgenic mice models, including APPswe/PS1M146L transgenic mice, were cited. The authors stated that the mouse model used in this study begin to develop amyloid plaques as early as 2.5 months of age. In our experience, line85 APPswe/PS1delta9 mice do not have any amyloid plaque at such an early age. It appears to me that authors used APPswe/PS1M146L mice, rather than line85 APPswe/PS1delta9 mice.