. Relationship of amyloid-beta burden with age-at-onset in Alzheimer's disease. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;

Abstract:

Objectives: To investigate the relationship between in vivo brain amyloid-beta (As) burden, measured by 11C-labeled Pittsburgh Compound B (11C-PiB) retention, and age-at-onset in Alzheimer's disease (AD) patients.

Design: Cross-sectional study. Setting: University Dementia Clinic. Participants: Twenty-two AD patients including 11 early-onset AD (EOAD: onset Intervention: 11C-PiB PET scans. Measurements: Both region of interest and voxel-based analyses were performed to compare 11C-PiB retention between EOAD and LOAD group, and to test linear relationship between age-at-onset and 11C-PiB retention.

Results: Both ROI- and voxel-based analyses revealed that EOAD patients had significantly higher 11C-PIB retentions than LOAD patients in diffuse brain regions including frontal, lateral parietal, lateral temporal and occipital cortex, and basal ganglia. Subgroup analyses showed that negative correlation between age-at-onset and 11C-PiB retention was significant in LOAD, but not in EOAD.

Conclusion: Our finding of a heavier As burden in the brain of living EOAD patients than LOAD patients is in agreement with those from postmortem studies. The inverse relationship between age-at-onset and As burden is possibly associated with aging-related decrease of brain or cognitive reserve, and with aging-related increase of brain vulnerability.

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