Lee DY, Han Choo IL, Kim JW, Seo EH, Lee DS, Kim YK, Kim SG, Park SY, Woo JI.
Relationship of amyloid-beta burden with age-at-onset in Alzheimer's disease.
Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
Objectives: To investigate the relationship between in vivo brain amyloid-beta (As) burden, measured by 11C-labeled
Pittsburgh Compound B (11C-PiB) retention, and age-at-onset in Alzheimer's disease (AD) patients.
Design: Cross-sectional study. Setting: University Dementia Clinic. Participants: Twenty-two AD patients
including 11 early-onset AD (EOAD: onset Intervention: 11C-PiB PET scans. Measurements: Both region of interest and voxel-based analyses were
performed to compare 11C-PiB retention between EOAD and LOAD group, and to test linear relationship between
age-at-onset and 11C-PiB retention.
Results: Both ROI- and voxel-based analyses revealed that EOAD patients had significantly higher 11C-PIB
retentions than LOAD patients in diffuse brain regions including frontal, lateral parietal, lateral temporal and
occipital cortex, and basal ganglia. Subgroup analyses showed that negative correlation between age-at-onset
and 11C-PiB retention was significant in LOAD, but not in EOAD.
Conclusion: Our finding of a heavier As burden in the brain of living EOAD patients than LOAD patients is in
agreement with those from postmortem studies. The inverse relationship between age-at-onset and As burden is
possibly associated with aging-related decrease of brain or cognitive reserve, and with aging-related increase of