Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD, Shen J.
Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.
J Biol Chem. 2004 Nov 5;279(45):46907-14. Epub 2004 Sep 1
PubMed.
To my knowledge, this is the first paper demonstrating the relationship between presenilin and inflammation, which might be associated with the paticular agressive nature of FAD caused by PS1 mutations. It seems, however, necessary and important to make a detailed comparison between PS-KO mice and FAD mutant PS-KI mice in order to obtain relevant insights into the pathogenic roles of PS mutations.
Comments
RIKEN Center for Brain Science
To my knowledge, this is the first paper demonstrating the relationship between presenilin and inflammation, which might be associated with the paticular agressive nature of FAD caused by PS1 mutations. It seems, however, necessary and important to make a detailed comparison between PS-KO mice and FAD mutant PS-KI mice in order to obtain relevant insights into the pathogenic roles of PS mutations.
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