. Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype. Dement Geriatr Cogn Disord. 2009;27(5):458-64. Epub 2009 May 7 PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)
Cohort
(N)
Measurement
Mean ± SD
Method;
Assay Name;
Manufacturer
Diagnostic
Criteria
Aβ42
(CSF)
AD
(47)
66 ± 34
pM
ELISA;
Other/Not Specified;
In-house
McKhann et al., 1984
Aβ42
(CSF)
CTRL-
CNC
(35)
98 ± 47
pM
ELISA;
Other/Not Specified;
In-house
Aβ42
(CSF)
MCI-AD
(14)
91 ± 71
pM
ELISA;
Other/Not Specified;
In-house
Petersen et al., 1999; McKhann et al., 1984
Aβ42
(CSF)
MCI-Stable
(14)
88 ± 48
pM
ELISA;
Other/Not Specified;
In-house
Petersen et al., 1999
tau-p181
(CSF)
AD
(47)
63 ± 25
ng/L
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-p181
(CSF)
CTRL-
CNC
(35)
41 ± 14
ng/L
ELISA;
Innotest;
Innogenetics
tau-p181
(CSF)
MCI-AD
(14)
74 ± 45
ng/L
ELISA;
Innotest;
Innogenetics
Petersen et al., 1999; McKhann et al., 1984
tau-p181
(CSF)
MCI-Stable
(14)
38 ± 16
ng/L
ELISA;
Innotest;
Innogenetics
Petersen et al., 1999
tau-total
(CSF)
AD
(47)
619 ± 291
ng/L
ELISA;
Innotest;
Innogenetics
McKhann et al., 1984
tau-total
(CSF)
CTRL-
CNC
(35)
248 ± 166
ng/L
ELISA;
Innotest;
Innogenetics
tau-total
(CSF)
MCI-AD
(14)
621 ± 418
ng/L
ELISA;
Innotest;
Innogenetics
Petersen et al., 1999; McKhann et al., 1984
tau-total
(CSF)
MCI-Stable
(14)
252 ± 216
ng/L
ELISA;
Innotest;
Innogenetics
Petersen et al., 1999

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