Bulteau AL, Verbeke P, Petropoulos I, Chaffotte AF, Friguet B. Proteasome inhibition in glyoxal-treated fibroblasts and resistance of glycated glucose-6-phosphate dehydrogenase to 20 S proteasome degradation in vitro. J Biol Chem. 2001 Dec 7;276(49):45662-8. Epub 2001 Sep 14 PubMed.

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- Benjamin Wolozin
  Boston University School of Medicine
- Posted: 29 Jun 2002
Increasing evidence focuses attention on proteasomal inhibition in neurodegeneration. Many protein aggregates have been shown to inhibit proteasomal activity, and inhibiting proteasomal activity is toxic to cells. This report now expands the types of protein modifications that can inhibit proteasomal activity, and suggests a mechanism by which glycation can be toxic.

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