Amieva H, Le Goff M, Millet X, Orgogozo JM, Pérès K, Barberger-Gateau P, Jacqmin-Gadda H, Dartigues JF.
Prodromal Alzheimer's disease: successive emergence of the clinical symptoms.
Ann Neurol. 2008 Nov;64(5):492-8.
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This paper contributes to our understanding of the duration and clinical features associated with the prodromal phase of Alzheimer disease. It reinforces neuroimaging studies indicating that neurodegeneration begins at least 10 years before current standards yield a diagnosis of dementia.
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