Siman R, Reaume AG, Savage MJ, Trusko S, Lin YG, Scott RW, Flood DG.
Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.
J Neurosci. 2000 Dec 1;20(23):8717-26.
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Important clarification in an ongoing debate.
Very interesting knock-in transgenic mice models where neither APP nor PS were overexpressed.