. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nat Cell Biol. 1999 Dec;1(8):479-85. PubMed.

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  1. This is an important paper as it reports a new PS1 function and suggests a mechanism for cellular damage of the PS1 FAD mutations.

  2. This is a nice cell biological study on AD. Perturbation at ER documented here is deeply related with all types of AD. Further investigation is welcome.