. Presenilin-1 mutations in Alzheimer's disease. Nature. 2000 Jun 1;405(6786):531-2. PubMed.

Recommends

Please login to recommend the paper.

Comments

Make a Comment

To make a comment you must login or register.

Comments on this content

  1. Mutations in PS1 have been shown to increase production of Ab42. This current publication suggests that mutations in PS1 might also affect cleavage at the N-terminus of Ab, leading to production of truncated Ab.

  2. This is a striking finding indicating that mutations in PS1 affect more than the C-terminus of Ab.

This paper appears in the following:

News

  1. Salzburg: Aβ’s N-terminal Shenanigans