. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6138-43. PubMed.


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  1. The large size of the solubilized complex is striking, and suggests that PS1 might act along with many other proteins in a gamma-secretase complex. This is a key step in proving that PS1 is gamma-secretase.

  2. More on gamma secretase and PS 1.