. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 1999 Apr 8;398(6727):518-22. PubMed.

Recommends

Please login to recommend the paper.

Comments

  1. Unquestionably this is a core paper for AD study.

  2. The abstract states: 'Thus the targeting of gamma-secretase for the treatment of Alzheimer's disease may risk toxicity caused by reduced Notch signalling.' A potentially important cautionary note.

Make a Comment

To make a comment you must login or register.