. Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9637-41. PubMed.

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  1. GSK-3 is proposed to be located at the upstream of pathology from the binding of presenilin-1. The total cascade will go to more complex but interesting issue.

  2. This ability of PS 1 to link GSK-3-beta with tau may be particularly important in view of the role that GSK-3-beta appears to play in phosphorylating tau.

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