. Pregnane X receptor (PXR) activation: A mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Proc Natl Acad Sci U S A. 2006 Aug 29; PubMed.


Please login to recommend the paper.


Make a Comment

To make a comment you must login or register.

Comments on Primary Papers and News

  1. The findings of Langmade, Gale, and colleagues, that allopregnanolone delayed progression of pathology and promoted survival, potentially through a PXR receptor-mediated mechanism, has exciting mechanistic and therapeutic implications. Mechanistically, allopregnanolone activation of the PXR receptor, leading to an increase in the cytochrome P450 enzyme CYP3A13, suggests a novel mechanism of allopregnanolone neuroprotection that brings the benefits of "liver" detox to the brain. Therapeutically, activating “liver-type” detoxification in brain may be a broad-spectrum strategy for promoting neurological health and defense against neurodegenerative insults.

    View all comments by Roberta Diaz Brinton

This paper appears in the following:


  1. Cholesterol Metabolites Protect Neurons in Niemann-Pick C Disease