Jack CR, Petersen RC, Xu YC, O'Brien PC, Smith GE, Ivnik RJ, Boeve BF, Waring SC, Tangalos EG, Kokmen E.
Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment.
Neurology. 1999 Apr 22;52(7):1397-403.
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'In older patients with MCI, hippocampal atrophy determined by premorbid MRI-based volume measurements is predictive of subsequent conversion to AD.' This appears to be evidence for a gross morphological change that might be considered to represent pre-clinical AD as might also be true of the presence of Braak stage I or II pathology.