Arruda-Carvalho M, Sakaguchi M, Akers KG, Josselyn SA, Frankland PW.
Posttraining ablation of adult-generated neurons degrades previously acquired memories.
J Neurosci. 2011 Oct 19;31(42):15113-27.
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Loss of memory trace-linked, postnatally born neurons has important implications for understanding the role of adult neurogenesis in normal and neuropathological age-related cognitive decline.
It would be important to establish whether in Alzheimer's disease, impairments in neurogenesis are manifested by loss of new neurons following memory formation and/or by the inability to generate or recruit enough new neurons for learning and memory.
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