Protas HD, Chen K, Langbaum JB, Fleisher AS, Alexander GE, Lee W, Bandy D, de Leon MJ, Mosconi L, Buckley S, Truran-Sacrey D, Schuff N, Weiner MW, Caselli RJ, Reiman EM.
Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease.
JAMA Neurol. 2013 Mar 1;70(3):320-5.
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This paper is very interesting. Longitudinal data will be the key to proving an anatomic pattern of progression, and the data here suggest a leading candidate hypothesis. These results are consistent with some findings we reported last year (Becker et al., 2011) relating amyloid more strongly to posterior cingulate/precuneus thinning of cortex than to hippocampal volume loss. The confound that many (including myself) are hoping to probe for this issue is the contribution of tau deposition in the medial temporal lobe versus other cortices. Ligands for that are coming.
Becker JA, Maye J, Gidicsin C, Rentz DR, Hedden T, Marshall G, Olson L, Buckner RL, Sperling RA, Johnson KA.
FDG metabolism, amyloid deposition and APOE status in cognitively normal elderly subjects.
Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
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