. A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia. Neurology. 1998 Apr;50(4):966-71. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)
Cohort
(N)
Measurement
Mean ± SD
Method;
Assay Name;
Manufacturer
Diagnostic
Criteria
albumin ratio
(CSF/Serum)
AD
(13)
8.9 ± 5.3
(CSF mg/L)/(Serum g/L)
Immunoelectrophoresis;
Other/Not Specified;
In-house
McKhann et al., 1984
albumin ratio
(CSF/Serum)
CTRL-
CNC
(29)
6.5 ± 2
(CSF mg/L)/(Serum g/L)
Immunoelectrophoresis;
Other/Not Specified;
In-house

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  1. The evidence supporting a BBB dysfunction in elderly demented patents in this paper adds further weight to a (uncertain) role of the BBB in AD and other pathologies.

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AlzBiomarker

  1. AD vs CTRL : albumin ratio (CSF/Serum and/or Plasma)