. PET imaging of beta-amyloid deposition in patients with mild cognitive impairment: a two year follow-up study. Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;

Abstract:

Background: Patients with amnestic mild cognitive impairment (MCI) have greater risk of conversion to AD. Increased brain amyloid burden in AD and MCI has been demonstrated with PET using [11C]PIB as a tracer. Objective: To evaluate change in beta-amyloid deposition in with MCI during 2 year follow-up. Methods: MCI patients and controls were studied with [11C]PIB PET, MRI and neuropsychometry at baseline and these investigations were repeated in MCI patients after follow-up.

Results: Those MCI patients converting to AD during follow-up had greater [11C]PIB retention in the posterior cingulate (p = 0.020), in the lateral frontal cortex (p = 0.006), in the temporal cortex (p=0.022), in the putamen (p = 0.041) and in the caudate nucleus (p=0.025) as compared to non-converters. In converters there was no significant change in [11C]PIB uptake, whereas an increase was seen as compared to baseline in non-converters in the anterior and posterior cingulate, temporal and parietal cortices and in the putamen. Hippocampal atrophy was greater in converters at baseline than in non-converters, but increased significantly in both groups during follow-up.

Conclusions: Hippocampal atrophy and amyloid deposition seem to dissociate during the evolution of MCI, the atrophy increasing clearly and [11C]PIB retention changing modestly when conversion to AD occurs. Longer followup is needed to determine whether non-converters would convert to AD later, which would suggest accelerated [11C]PIB retention preceding clinical conversion.

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