. PET imaging of amyloid deposition in patients with mild cognitive impairment: A two year follow-up study. Human Amyloid Imaging 2010 Meeting Abstracts. 2010 April 9;

Abstract:

Background: Because of the ongoing development of disease modifying therapies, it is potentially of great clinical value to identify subjects at a high risk of developing Alzheimer’s disease (AD). Patients with amnestic mild cognitive impairment (MCI) represent a group of individuals with greater risk of conversion to AD. Increased brain amyloid burden in AD and MCI has been demonstrated with PET using [11C]PIB.

Objective: To compare levels of beta-amyloid deposition during an approximately 24-month (range 16-39) followup period in 29 MCI patients, 12 of whom remained MCI and 17 of whom converted to AD, and in 13 healthy elderly control individuals.

Method: Patients with MCI and controls were studied with [11C]PIB PET, MRI and neuropsychometry at baseline. These investigations were repeated in MCI patients after follow-up for 24 months.

Results: At group level, patients with MCI had increased [11C]PIB uptake in several cortical regions. Those MCI patients converting to AD had greater [11C]PIB retention in the posterior cingulate (p=0.020), in the lateral frontal cortex (p=0.006), in the temporal cortex (p=0.022), in the putamen (p=0.041) and in the caudate nucleus (p=0.025) as compared to non-converters. In the MCI converters, there was no significant change in [11C]PIB uptake during the follow-up, whereas [11C]PIB uptake increased as compared to baseline in the MCI non-converters in the anterior and posterior cingulates, temporal and parietal cortices and in the putamen. Hippocampal atrophy was greater in MCI converters at baseline than in non-converters, but increased significantly in both groups during follow-up.

Conclusions: Hippocampal atrophy and amyloid deposition seem to dissociate during the evolution of MCI, the atrophy increasing clearly and [11C]PIB retention changing modestly when conversion to AD occurs. Future studies will determine whether the increased [11C]PIB uptake and hippocampal atrophy in MCI non-converts will predict conversion to AD during longer follow-up.

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  1. Toronto: HAI Amyloid Imaging Conference Abstracts