Li X, De Sarno P, Song L, Beckman JS, Jope RS. Peroxynitrite modulates tyrosine phosphorylation and phosphoinositide signalling in human neuroblastoma SH-SY5Y cells: attenuated effects in human 1321N1 astrocytoma cells. Biochem J. 1998 Apr 15;331 ( Pt 2):599-606. PubMed.
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Li et al describe the effects of peroxynitrite (free radical generated in nitric oxide pathways) on second messenger systems in cultured human tumor cells. Although the authors point to the possible relevance of their findings to AD, no direct link to AD is established.
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