. Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide. J Neurosci. 2004 Dec 1;24(48):10908-17. PubMed.

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  1. This work may open a new avenue for prevention and treatment through regulating Aβ levels in the brain. It would be interesting to know the mechanism by which PPARγ activation leads to the decrease of Aβ levels.

  2. This is a good paper, suggesting a new focus, and I only have one question. Is it clearance of soluble Aβ or aggregated Aβ?