. PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. J Biol Chem. 2002 Oct 18;277(42):39062-5. PubMed.


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  1. The γ-secretase complex gains more integral members necessary for function. Similar results reported at Int'l AD meeting in Sweden this summer but Haass lab wins this sprint!

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  1. Homing in on Roles for PS Complex Proteins APH-1 and PEN-2