Mohajeri MH, Saini K, Schultz JG, Wollmer MA, Hock C, Nitsch RM.
Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation.
J Biol Chem. 2002 Sep 6;277(36):33012-7.
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The paper by Mohajeri et al. is interesting in that the increased vulnerability of APPsw mice to seizure induced cell death could be due to APP overexpression or due to increased levels of soluble Abeta. Evidence that increased vulnerability to death is due to Abeta is that an antibody against Abeta (not APP) decreased cell death when passively administered. This suggests that under certain injury conditions, even soluble forms of Abeta in the absence of plaques can be injurious.
Please do not miss the following comments related to this article: Alzheimer’s anti-amyloid vaccination and statins: two approaches, one dogma. The time for change. Koudinov and Koudinova BMJ 20 March 2002 [ Full Text ] Alzheimer's disease and amyloid beta protein Koudinov AR et al Science online, Published 25 June 2002 [ Full Text ] Dangers of the amyloid-beta vaccination. Smith MA et al. Acta Neuropathol (Berl) 2002 Jul;104(1):110 [ PubMed ] Call for Elan to publish Alzheimer's trial details Bishop et al. Nature. 416(6882): 677, 2002 Apr 18. [ PubMed ]
Smith MA, Joseph JA, Atwood CS, Perry G.
Dangers of the amyloid-beta vaccination.
Acta Neuropathol. 2002 Jul;104(1):110.
Bishop GM, Robinson SR, Smith MA, Perry G, Atwood CS.
Call for Elan to publish Alzheimer's trial details.
Nature. 2002 Apr 18;416(6882):677.