. Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5956-61. PubMed.

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  1. These findings represent an intriguing potential convergence with our own data (see ARF related news story), which demonstrated that parkin forms a ubiquitin ligase complex that downregulates cyclin E. Cyclin E has been shown to accumulate in some mammary tumors (Keyomarsi et al., 2002), and hSel-10/Cdc4, which we have shown to be a part of the parkin complex, is sporadically mutated in at least one breast cancer line (Strohmaier et al., 2001). Clearly, an important next step is to look at cyclin E expression at the mRNA and protein levels in tumors with loss of heterozygosity linked to the parkin locus. Perhaps parkin mutations and cyclin E accumulation are double-edged swords, leading to neurodegeneration in some cases and to cancer in others.

    References:

    . Cyclin E and survival in patients with breast cancer. N Engl J Med. 2002 Nov 14;347(20):1566-75. PubMed.

    . Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature. 2001 Sep 20;413(6853):316-22. PubMed.

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