. The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore. J Neurosci. 2009 Mar 25;29(12):3781-91. PubMed.

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  1. Monif et al. have published an excellent paper. It provides independent confirmation of our earlier finding that the P2X7 receptor, far from being a mere "death receptor," is on the contrary a growth-promoting receptor (see Baricordi et al., 1999). We strengthened this finding in subsequent papers (Adinolfi et al., 2002; Adinolfi et al., 2005; Raffaghello et al., 2006). We also showed, in collaboration with Claudia Verderio and Maria Pia Abbracchio, that the P2X7 receptor had a crucial role in sustaining growth of microglia and discussed implications for neurodegenerative diseases (Bianco et al., 2006). In two recent papers we have further analyzed the molecular basis of the trophic effect of P2X7 (Adinolfi et al., 2009), and discussed the implications in cancer (Di Virgilio et al., 2009).

    See also:

    Di Virgilio F, Ferrari D, and Adinolfi E. (2009) P2X7: a growth-promoting receptor. Purinergic Signal in press.

    References:

    . Increased proliferation rate of lymphoid cells transfected with the P2X(7) ATP receptor. J Biol Chem. 1999 Nov 19;274(47):33206-8. PubMed.

    . P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia. Blood. 2002 Jan 15;99(2):706-8. PubMed.

    . Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth. Mol Biol Cell. 2005 Jul;16(7):3260-72. PubMed.

    . The P2X7 receptor sustains the growth of human neuroblastoma cells through a substance P-dependent mechanism. Cancer Res. 2006 Jan 15;66(2):907-14. PubMed.

    . A role for P2X7 in microglial proliferation. J Neurochem. 2006 Nov;99(3):745-58. PubMed.

    . Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis. J Biol Chem. 2009 Apr 10;284(15):10120-8. PubMed.

  2. Excellent work by Williams and DeVirgilio. But what is the stimulant to the P2X7 receptor that stirs the immune cells in glia to activate from quiescence in AD?

    View all comments by carmine palermo
  3. Monif et al. have published an excellent paper. It provides independent confirmation of our earlier finding that the P2X7 receptor, far from being a mere "death receptor," is on the contrary a growth-promoting receptor (see Baricordi et al., 1999). We strengthened this finding in subsequent papers (Adinolfi et al., 2002; Adinolfi et al., 2005; Raffaghello et al., 2006). We also showed, in collaboration with Claudia Verderio and Maria Pia Abbracchio, that the P2X7 receptor had a crucial role in sustaining growth of microglia and discussed implications for neurodegenerative diseases (Bianco et al., 2006). In two recent papers we have further analyzed the molecular basis of the trophic effect of P2X7 (Adinolfi et al., 2009), and discussed the implications in cancer (Di Virgilio et al., 2009).

    References:

    . Increased proliferation rate of lymphoid cells transfected with the P2X(7) ATP receptor. J Biol Chem. 1999 Nov 19;274(47):33206-8. PubMed.

    . P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia. Blood. 2002 Jan 15;99(2):706-8. PubMed.

    . Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth. Mol Biol Cell. 2005 Jul;16(7):3260-72. PubMed.

    . The P2X7 receptor sustains the growth of human neuroblastoma cells through a substance P-dependent mechanism. Cancer Res. 2006 Jan 15;66(2):907-14. PubMed.

    . A role for P2X7 in microglial proliferation. J Neurochem. 2006 Nov;99(3):745-58. PubMed.

    . Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis. J Biol Chem. 2009 Apr 10;284(15):10120-8. PubMed.

    . P2X(7): a growth-promoting receptor-implications for cancer. Purinergic Signal. 2009 Jun;5(2):251-6. Epub 2009 Mar 4 PubMed.

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