Friedhoff P, von Bergen M, Mandelkow EM, Davies P, Mandelkow E.
A nucleated assembly mechanism of Alzheimer paired helical filaments.
Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15712-7.
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The original theory for protein polymerization was established on actin molecule by Dr. Osawa. He said that the first nucleation step is the rate-determinant reaction while the second elongation step is relatively fast. This was applied to microtubule, amyloid and now to tau. Tau dimer may be important for seeding [PHFs].