. A nucleated assembly mechanism of Alzheimer paired helical filaments. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15712-7. PubMed.


Please login to recommend the paper.


Make a Comment

To make a comment you must login or register.

Comments on this content

  1. The original theory for protein polymerization was established on actin molecule by Dr. Osawa. He said that the first nucleation step is the rate-determinant reaction while the second elongation step is relatively fast. This was applied to microtubule, amyloid and now to tau. Tau dimer may be important for seeding [PHFs].