Giedraitis V, Hedlund M, Skoglund L, Blom E, Ingvast S, Brundin R, Lannfelt L, Glaser A.
New Alzheimer's disease locus on chromosome 8.
J Med Genet. 2006 Dec;43(12):931-5.
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An interesting paper assessing a dozen Swedish families with AD in an attempt to identify a new locus. The authors present data that support (but do not prove) a new locus for AD on chr 8. This is based on a segregating haplotype across the centromere of chr 8 in two distinct families. As the authors note, more affected members or families and the identification of a single ancestral haplotype would strengthen this argument.
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