. Neuronal endosomal/lysosomal membrane destabilization activates caspases and induces abnormal accumulation of the lipid secondary messenger ceramide. Brain Res Bull. 2003 Feb 15;59(6):523-31. PubMed.


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  1. Very provocative. It would be more relevant if the pathway is proven to be present in adult brain in an in vivo paradigm.

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